Open Access<p>Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells</p>
Author(s) -
Jie Liu,
Kehua Que,
Yangqiu Liu,
Chengcheng Zang,
Jing Wen
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s255288
Subject(s) - medicine , tumor necrosis factor alpha , cancer research , microbiology and biotechnology , biology
Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is a promiscuous chemical nociceptor involved in the perception of cold hypersensitivity, mechanical hyperalgesia and inflammatory pain in human odontoblasts (HODs). Here, we aimed to study the underlying mechanism in which inflammatory cytokine tumor necrosis factor (TNF)-α regulated the expression of TRPA1 channel at both cellular and subcellular levels.