Open Access<p>Electroacupuncture Regulates Pain Transition by Inhibiting the mGluR5-PKCϵ Signaling Pathway in the Dorsal Root Ganglia</p>
Author(s) -
Sisi Wang,
Junying Du,
Fangbing Shao,
Wen Wang,
Haiju Sun,
Xiaomei Shao,
Yi Liang,
Boyi Liu,
Jianqiao Fang,
Junfan Fang
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s251948
Subject(s) - medicine , electroacupuncture , metabotropic glutamate receptor 5 , protein kinase c , zusanli , glutamate receptor , pharmacology , endocrinology , signal transduction , metabotropic glutamate receptor , receptor , acupuncture , microbiology and biotechnology , pathology , biology , alternative medicine
Acute pain can transition to chronic pain, presenting a major clinical challenge. Electroacupuncture (EA) can partly prevent the transition from acute to chronic pain. However, little is known about the mechanisms underlying the effect of EA. This study investigated the effect of EA on pain transition and the activation of metabotropic glutamate receptor 5 (mGluR5)-protein kinase C epsilon (PKCε) signaling pathway in the dorsal root ganglia (DRG).