Open Access<p>Early Blockade of EphA4 Pathway Reduces Trigeminal Neuropathic Pain</p>
Author(s) -
Minji Kim,
Jo-Young Son,
Jae Kyun Ju,
Dongbin Ahn
Publication year - 2020
Publication title -
journal of pain research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s249185
Subject(s) - medicine , neuropathic pain , trigeminal nerve , nerve injury , inferior alveolar nerve , anesthesia , blockade , allodynia , nociception , orofacial pain , hyperalgesia , molar , receptor , surgery , dentistry
Although the Eph receptor plays an important role in the development of neuropathic pain following nerve injury, there has been no evidence of the participation of the ephrin A4 receptor (EphA4) in the development of trigeminal neuropathic pain. The present study investigated the role of EphA4 in central nociceptive processing in rats with inferior alveolar nerve injury.