Open Access<p>Sonic Hedgehog Signaling Contributes to Chronic Post-Thoracotomy Pain via Activating BDNF/TrkB Pathway in Rats</p>
Author(s) -
Yi Yang,
Xiaoyan Wang,
Xuan Zhang,
Shaohua You,
Long Feng,
Yunliang Zhang,
Yizheng Shi,
Yao Xü,
Hong Zhang
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s245515
Subject(s) - tropomyosin receptor kinase b , smoothened , cyclopamine , medicine , tropomyosin receptor kinase a , hedgehog signaling pathway , endocrinology , signal transduction , neurotrophic factors , neurotrophin , receptor , biology , microbiology and biotechnology
Some patients undergoing thoracotomy may suffer from chronic post-thoracotomy pain (CPTP). Treatment of CPTP has been a clinical challenge and the underlying mechanisms of CPTP remain elusive. Recently, sonic hedgehog (Shh) signaling has been shown to be associated with various pain states but its role in the pathogenesis of CPTP is still unclear.