Open Access<p>Depression of Mitochondrial Function in the Rat Skeletal Muscle Model of Myofascial Pain Syndrome Is Through Down-Regulation of the AMPK-PGC-1α-SIRT3 Axis</p>
Author(s) -
Le Ye,
Mingli Li,
Zhankui Wang,
Zhongwei Yang,
Jingyuan Zhang,
Hongwei Fang,
Zhenzhou He,
Xiangrui Wang
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s233583
Subject(s) - sirt3 , tfam , mitochondrial biogenesis , ampk , mitochondrion , phosphorylation , endocrinology , medicine , microbiology and biotechnology , skeletal muscle , biology , protein kinase a , gene , acetylation , sirtuin , biochemistry
The causative mechanisms triggering myofascial pain syndrome (MPS) are still in debate. It is becoming evident that mitochondrial dysfunction may regulate pathways controlling MPS. The aim of this study was to investigate whether AMPK-PGC-1α-SIRT3 axis is associated with depression of mitochondrial function in the rat MPS model.