Open Access<p>Ameliorative Effects Of N-Acetylcysteine As Adjunct Therapy On Symptoms Of Painful Diabetic Neuropathy</p>
Author(s) -
Narges Heidari,
Firozeh Sajedi,
Younes Mohammadi,
Mahtabalsadat Mirjalili,
Maryam Mehrpooya
Publication year - 2019
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s228255
Subject(s) - medicine , acetylcysteine , adjunct , diabetic neuropathy , diabetes mellitus , endocrinology , antioxidant , biochemistry , chemistry , philosophy , linguistics
Painful diabetic neuropathy (PDN) is a variant of diabetic peripheral neuropathy which is highly prevalent and distressing in diabetic patients. Despite its high burden, the optimal treatment of PDN has remained a clinical challenge. To explain the emergence and maintenance of PDN, increasing attention has been focused on dimensions of inflammation and oxidative toxic stress (OTS). Accordingly, the aim of this study was to investigate the effects of oral N-acetylcysteine (NAC), an agent with known anti-oxidant and anti-inflammatory effects, as an adjunct therapy in patients suffering from PDN.