Open Access<p>Overexpression Of miR138 Ameliorates Spared Sciatic Nerve Injury-Induced Neuropathic Pain Through The Anti-Inflammatory Response In Mice</p>
Author(s) -
Benfan Zhu,
Jie Gao,
Yeling Ouyang,
Zhiqiang Hu,
Xiangdong Chen
Publication year - 2019
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s219462
Subject(s) - sni , neuropathic pain , medicine , proinflammatory cytokine , sciatic nerve , nerve injury , hyperalgesia , spinal cord , sciatic nerve injury , neuroprotection , allodynia , anesthesia , microglia , inflammation , spinal cord injury , pharmacology , nociception , receptor , biochemistry , chemistry , psychiatry , hydrolysis , acid hydrolysis
The emerging role of inflammation in the initiation and maintenance of neuropathic pain has been confirmed. Previous studies have reported that miR138 has neuroprotective and anti-inflammatory effects in animal models of spinal cord injury and in human coronary artery endothelial cell injury, while its effect on neuropathic pain is still not known. As the mechanism of neuropathic pain remains unclear, we investigated whether miR138 is involved in the development of neuropathic pain and the role of miR138 in the modulation of inflammation in the spinal cord in a mouse model of neuropathic pain induced by spared sciatic nerve injury (SNI).