Open Access<p>A randomized, placebo- and active-controlled, multi-country, multi-center parallel group trial to evaluate the efficacy and safety of a fixed-dose combination of 400 mg ibuprofen and 100 mg caffeine compared with ibuprofen 400 mg and placebo in patients with acute lower back or neck pain</p>
Author(s) -
HansGeorg Predel,
Caty Ebel-Bitoun,
Robert Lange,
Thomas Weiser
Publication year - 2019
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s217045
Subject(s) - ibuprofen , medicine , placebo , tolerability , analgesic , anesthesia , morning , clinical endpoint , randomized controlled trial , caffeine , adverse effect , pharmacology , alternative medicine , pathology
Ibuprofen is a well-established analgesic for acute pain symptoms. In several acute pain models, caffeine has demonstrated an analgesic adjuvant effect. This randomized trial (NCT03003000) was designed to compare the efficacy of a fixed-dose combination of ibuprofen and caffeine with ibuprofen or placebo for the treatment of acute lower back/neck pain.