Open Access<p>Systemic Injection of Thalidomide Prevent and Attenuate Neuropathic Pain and Alleviate Neuroinflammatory Response in the Spinal Dorsal Horn</p>
Author(s) -
Hao Xu,
Shajie Dang,
Yuanyuan Cui,
Zhenyu Wu,
Junfeng Zhang,
Xiao Peng Mei,
Yixuan Feng,
Yunqing Li
Publication year - 2019
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s213112
Subject(s) - medicine , neuropathic pain , glial fibrillary acidic protein , intraperitoneal injection , astrocyte , analysis of variance , microglia , spinal cord , anesthesia , tumor necrosis factor alpha , endocrinology , immunohistochemistry , inflammation , central nervous system , psychiatry
Thalidomide (Tha) has been shown to exert immunomodulatory and anti-inflammatory properties. Whether Tha can alleviate spinal nerve ligation (SNL)-induced neuropathic pain (NP) is still unclear. This study aimed to investigate the therapeutic effect of Tha on the SNL-induced NP and further explore the potential analgesic mechanisms of Tha.