Open AccessLow Level FLT3LG is a Novel Poor Prognostic Biomarker for Cervical Cancer with Immune Infiltration
Author(s) -
Lihua chen,
Yuxuan Huang,
Bin Dong,
Yu Gu,
Ye Li,
Wei Cang,
Pengming Sun,
Yang Xiang
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s384908
Subject(s) - cervical cancer , medicine , biomarker , oncology , immune system , breast cancer , immunotherapy , nomogram , cancer , immunology , biology , biochemistry
The FMS-related tyrosine kinase 3 (FLT3) ligand (FLT3LG), a growth factor, binds to FLT3 on dendritic cell (DCs) to enhance their differentiation and expansion. It has shown great potential as an immunotherapy target for cancers. However, the expression and function of FLT3LG in cervical cancer remain largely unknown.