Open AccessInhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results
Author(s) -
Zhiquan Ding,
Zhenzhong Zhong,
Jun Wang,
Run Zhang,
Jinlian Shao,
Yulong Li,
Guiwei Wu,
Huiru Tu,
Wen Yuan,
Haitao Sun,
Qinghua Wang
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s384020
Subject(s) - pyroptosis , inflammasome , neuroinflammation , western blot , microglia , caspase 1 , proinflammatory cytokine , pharmacology , inflammation , medicine , immunology , chemistry , biochemistry , gene
Neuroinflammation plays an important role following intracerebral hemorrhage (ICH). NLRP3 inflammasome-mediated pyroptosis contributes to the mechanism of neuroinflammation. It has been reported that dendritic cell-associated C-type lectin-1 (Dectin-1) activation triggers inflammation in neurological diseases. However, the role of Dectin-1 on NLRP3 inflammasome-mediated pyroptosis after ICH remains unclear. Here, we aimed to explore the effect of Dectin-1 on NLRP3 inflammasome-mediated pyroptosis and neuroinflammation after ICH.