Open AccessMetallothionein-1 is Positively Correlated with Inflammation and Ankylosing Spondylitis Activity
Author(s) -
Yanmei Ma,
Jing Du,
Zhihua Yin,
Hanying Dai,
Yazhi Wei,
Yuhao Xia,
Lingyun Li,
Zhizhong Ye,
Zhong Huang
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s382827
Subject(s) - proinflammatory cytokine , ankylosing spondylitis , medicine , erythrocyte sedimentation rate , inflammation , rheumatoid arthritis , tumor necrosis factor alpha , pathogenesis , immunology , spondylitis , c reactive protein , interleukin 6
Ankylosing spondylitis (AS) is a common form of chronic inflammatory rheumatic disease. Metallothionein-1 (MT-1) has been known to play an immunosuppressive role in various noninfectious inflammatory diseases, especially osteoarthritis and rheumatoid arthritis, thus inhibiting inflammation and pathogenesis in various diseases. However, whether MT-1 is related to AS is unclear. Here, we examined the levels of MT-1 in patients with AS and its correlation with the disease activity, complication, clinical indexes, and inflammatory cytokines and attempted to explain the effect of MT-1 on inflammation in AS.