Open Accessα-Chaconine Facilitates Chondrocyte Pyroptosis and Nerve Ingrowth to Aggravate Osteoarthritis Progression by Activating NF-κB Signaling
Author(s) -
Zhiguo Zhang,
Fangda Fu,
Yishan Bian,
Huihao Zhang,
Sai Yao,
Chengcong Zhou,
Yuying Ge,
Huan Luo,
Yuying Chen,
W. Ji,
Kun Tian,
Ming Yue,
Weibin Du,
Hongting Jin,
Peijian Tong,
Chengliang Wu,
Hongfeng Ruan
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s382675
Subject(s) - chondrocyte , osteoarthritis , pyroptosis , medicine , pathology , cartilage , population , biology , immunology , anatomy , inflammation , alternative medicine , inflammasome , environmental health
With the rapid growth of the elderly population, the incidence of osteoarthritis (OA) increases annually, which has attracted extensive attention in public health. The roles of dietary intake in controlling joint disorders are perhaps one of the most frequently posed questions by OA patients, while the information about the interaction between dietary intake and OA based on scientific research is limited. α-Chaconine is the richest glycoalkaloid in eggplants such as potatoes. Previous evidence suggests that α -Chaconine is a toxic compound to nervous and digestive systems with potentially severe and fatal consequences for humans and farm animals, but its effect on OA development remains obscure.