Open AccessYAP Activates STAT3 Signalling to Promote Colonic Epithelial Cell Proliferation in DSS-Induced Colitis and Colitis Associated Cancer
Author(s) -
Feihong Deng,
Zengrong Wu,
Mengmeng Xu,
Pianpian Xia
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s377077
Subject(s) - colitis , cancer research , stat3 , cell growth , downregulation and upregulation , microbiology and biotechnology , biology , signal transduction , chemistry , immunology , gene , biochemistry , genetics
Yes-associated protein (YAP) is a key transcriptional coactivator of cell proliferation and differentiation. In this study, we sought to identify the roles of YAP in colonic epithelial regeneration and tumourigenesis.