Open AccessModerate Dose Irradiation Induces DNA Damage and Impairments of Barrier and Host Defense in Nasal Epithelial Cells in vitro
Author(s) -
Yueying Yang,
Jing Liu,
Yitong Liu,
Hsiao-Hui Ong,
Qian-Min Chen,
Ce-Belle Chen,
Mark Thong,
Xinni Xu,
Suizi Zhou,
Qianhui Qiu,
De Yun Wang
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s369385
Subject(s) - inflammation , respiratory tract , dna damage , basal (medicine) , mucus , medicine , respiratory system , in vitro , immunology , dna , cancer research , biology , biochemistry , ecology , insulin
Radiotherapy (RT) is the mainstay treatment for head and neck cancers. However, chronic and recurrent upper respiratory tract infections and inflammation have been commonly reported in patients post-RT. The underlying mechanisms remain poorly understood.