Open AccessThe Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy
Author(s) -
Zhengquan Dong,
Zhou Ma,
Mei-Ju Yang,
Linlin Cong,
Ruipeng Zhao,
Liyun Cheng,
Jian Sun,
Yunfei Wang,
Rong Yang,
Xiaochun Wei,
Pengcui Li
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s365545
Subject(s) - chondrocyte , aggrecan , hdac4 , cartilage , sox9 , runx2 , osteoarthritis , immunohistochemistry , muscle hypertrophy , type ii collagen , endocrinology , biology , medicine , pathology , gene expression , microbiology and biotechnology , histone deacetylase , histone , anatomy , gene , genetics , articular cartilage , alternative medicine
To determine the role of histone deacetylase 4 (HDAC4)-controlled chondrocyte hypertrophy in the onset and development of age-related osteoarthritis (OA).