Open Accessα-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation
Author(s) -
Mateusz Maciejczyk,
Ewa Żebrowska,
Miłosz Nesterowicz,
Elżbieta Supruniuk,
Barbara Choromańska,
Adrian Chabowski,
Małgorzata Żendzian-Piotrowska
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s358799
Subject(s) - endocrinology , medicine , insulin resistance , insulin , neuroinflammation , oxidative stress , chemistry , insulin degrading enzyme , biology , inflammation
Oxidative stress underlies metabolic diseases and cognitive impairment; thus, the use of antioxidants may improve brain function in insulin-resistant conditions. We are the first to evaluate the effects of α-lipoic acid (ALA) on redox homeostasis, sphingolipid metabolism, neuroinflammation, apoptosis, and β-amyloid accumulation in the cerebral cortex and hypothalamus of insulin-resistant rats.