Open AccessExperimental and Theoretical Insights on Chemopreventive Effect of the Liposomal Thymoquinone Against Benzo[a]pyrene-Induced Lung Cancer in Swiss Albino Mice
Author(s) -
Arif Khan,
Mohammed A Alsahli,
Mohammad Abdullah Aljasir,
Hamzah Maswadeh,
Mugahid A Mobark,
Faizul Azam,
Khaled S. Allemailem,
Faris Alrumaihi,
Fahad A. Alhumaydhi,
Ahmad Almatroudi,
Naif Alsuhaymi,
Masood Alam Khan
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s358632
Subject(s) - thymoquinone , benzo(a)pyrene , pharmacology , chemistry , lung cancer , glutathione , apoptosis , antioxidant , carcinogen , biochemistry , cancer research , medicine , enzyme , pathology
Thymoquinone (TQ), a phytoconstituent of Nigella sativa seeds, has been studied extensively in various cancer models. However, TQ's limited water solubility restricts its therapeutic applicability. Our work aims to prepare the novel formulation of TQ and assess its chemopreventive potential in chemically induced lung cancer animal model.