Open AccessRole of Ferroptosis in Fibrotic Diseases
Author(s) -
Jian Zhou,
Tao Yuan,
Rurong Wang,
Xuehan Li
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s358470
Subject(s) - fibrosis , mechanism (biology) , pulmonary fibrosis , homeostasis , cell metabolism , gpx4 , cancer research , medicine , biology , cell , oxidative stress , microbiology and biotechnology , pathology , superoxide dismutase , biochemistry , philosophy , epistemology , glutathione peroxidase
Ferroptosis is a unique and pervasive form of regulated cell death driven by iron-dependent phospholipid peroxidation. It results from disturbed cellular metabolism and imbalanced redox homeostasis and is regulated by various cellular metabolic pathways. Recent preclinical studies have revealed that ferroptosis may be an attractive therapeutic target in fibrotic diseases, such as liver fibrosis, pulmonary fibrosis, kidney fibrosis, and myocardial fibrosis. This review summarizes the latest knowledge on the regulatory mechanism of ferroptosis and its roles in fibrotic diseases. These updates may provide a novel perspective for the treatment of fibrotic diseases as well as future research.