Open AccessHSP70 Ameliorates Septic Acute Kidney Injury via Binding with TRAF6 to Inhibit of Inflammation-Mediated Apoptosis
Author(s) -
Yiqiu Zhang,
Chenlu Song,
Wei Ni,
Qing Pei,
Caixia Wang,
Youguo Ying,
Min Yao
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s352717
Subject(s) - inflammation , kidney , apoptosis , acute kidney injury , western blot , hsp70 , tumor necrosis factor alpha , proinflammatory cytokine , lipocalin , cytokine , medicine , immunology , cancer research , heat shock protein , biology , biochemistry , gene
Acute kidney injury (AKI) is one of the most severe complications of sepsis, the pathological features of which are excessive inflammation and programmed cell death of resident renal cells. Heat shock protein 70 (HSP70) is a critical stress protein for repressing inflammation, however, its role in AKI is not fully understood. The current study aimed to determine the protective effect of HSP70 on septic AKI and its underlying mechanisms.