Open AccessGut Microbiota Mediates the Susceptibility of Mice to Sepsis-Associated Encephalopathy by Butyric Acid
Author(s) -
Huidan Zhang,
Jing Xu,
Qingrui Wu,
Heng Fang,
Xin Shao,
Xin Ouyang,
Zhimei He,
Yiyu Deng,
Chunbo Chen
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s350566
Subject(s) - butyrate , gut flora , sepsis , sodium butyrate , butyric acid , neuroinflammation , biology , oxidative stress , microbiology and biotechnology , immunology , pharmacology , inflammation , biochemistry , fermentation , gene
Neuroinflammation plays an important part in the pathophysiology of sepsis-associated encephalopathy (SAE). Gut microbiota and gut brain axis are considered as important mediators in the development of neurological diseases. The aim of this study was to investigate the role of intestinal microbiota in sepsis-related brain injury and to explore the underlying mechanisms.