Open AccessAssociation of Growth and Differentiation Factor 15 in Rheumatoid Arthritis
Author(s) -
He YW,
He CS
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s350281
Subject(s) - gdf15 , rheumatoid arthritis , medicine , genotype , allele , growth differentiation factor , rheumatoid factor , arthritis , immunology , biology , gene , genetics , bone morphogenetic protein
Rheumatoid arthritis (RA) is an inflammatory rheumatic disease, which has been demonstrated to correlate with mutated genetics. Growth and differentiation factor 15 (GDF-15) is a member of the transforming growth factor-β superfamily and is expressed in different organs, tissues and immune cells. To date, limited studies have evaluated plasma levels of GDF-15 in RA patients, and whether GDF-15 gene polymorphisms correlate with RA risk in the Chinese Han population has not been clarified.