Open AccessTLR3 Expression is a Potential Prognosis Biomarker and Shapes the Immune-Active Tumor Microenvironment in Esophageal Squamous Cell Carcinoma
Author(s) -
Ruibing Su,
Liang Cai,
Pan Xiong,
Zhiwei Liu,
Shaobin Chen,
Xi Liu,
Runhua Lin,
Zhijin Lei,
Dan Tian,
Min Su
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s348786
Subject(s) - immune system , cancer research , tumor microenvironment , tlr3 , innate immune system , cd8 , immunohistochemistry , inflammation , immunotherapy , chemokine , medicine , biology , immunology , toll like receptor
Toll-like receptor 3 (TLR3) not only plays a crucial role in innate immune and inflammation but also in anti-cancer immunity. Nevertheless, the clinicopathological outcome of TLR3 in ESCC is still ambiguous.