Open AccessSCD1-Fatty Acid Desaturase Inhibitor MF-438 Alleviates Latent Inflammation Induced by Preservative-Free Prostaglandin Analog Eye Drops
Author(s) -
Anna Pacwa,
Joanna Machowicz,
Alicja Wojtyniak,
Marita PietruchaDutczak,
Elisa Toropainen,
Ali Koskela,
Ewa Mrukwa–Kominek,
Joanna LewinKowalik,
Adrian Smędowski
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s347784
Subject(s) - preservative , chemistry , fatty acid , food science , inflammation , biochemistry , biology , immunology
Prostaglandin analogs are the first line of treatment in patients with glaucoma. Recently, many preservative-free prostaglandin analogs have been marketed to increase their tolerance in chronic use. However, potentially safer formulations have been reported to induce inflammation within ocular surface and adnexa, associated with pronounced activation of tissue macrophages.