Open AccessThe Transcriptional Landscapes and Key Genes in Brain Arteriovenous Malformation Progression in a Venous Hypertension Rat Model Revealed by RNA Sequencing
Author(s) -
Shifu Li,
Wengui Tao,
Zheng Huang,
Langchao Yan,
Bin Chen,
Chudai Zeng,
Fenghua Chen
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s347754
Subject(s) - gene , biology , venous hypertension , rna , genetics , arteriovenous malformation , venous malformation , computational biology , medicine , surgery
Brain arteriovenous malformations (bAVM) are abnormal vascular lesions characterized by direct connections between arteries and veins without an intervening capillary bed. The primary goal for brain AVM treatment is to prevent rupture and hemorrhage; however, the underlying molecular mechanisms are still unknown.