Open AccessMicroRNA miR-24-3p Mediates the Negative Regulation of Lipopolysaccharide-Induced Endometrial Inflammatory Response by Targeting TNF Receptor-Associated Factor 6 (TRAF6)
Author(s) -
Ayodele Olaolu Oladejo,
Yajuan Li,
Bereket Habte Imam,
Xiaoyu Ma,
Wenxiang Shen,
Xiaohu Wu,
Wei Jiang,
Jie Yang,
Yanan Lv,
Xuezhi Ding,
Shengyi Wang,
Zuoting Yan
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s347293
Subject(s) - lipopolysaccharide , mapk/erk pathway , endometritis , tumor necrosis factor alpha , innate immune system , proinflammatory cytokine , western blot , inflammation , downregulation and upregulation , immune system , microrna , biology , immunology , chemistry , signal transduction , microbiology and biotechnology , gene , pregnancy , biochemistry , genetics
Endometritis is a female reproductive disease that affects the cattle industries development and microRNAs (miRNAs) play a pivotal role and critical regulators of the innate immune response in varieties of diseases. The present study intends to investigate the regulatory role of miR-24-3p in the innate immune response involved in endometritis and evaluate its therapeutic potential.