Open AccessProphylactic Effects of NFκB Essential Modulator–Binding Domain Peptides on Bone Infection: An Experimental Study in a Rabbit Model
Author(s) -
Wenjiao Wu,
Changliang Xia,
Shuanji Ou,
Yang Yang,
Xiaozhong Zhou,
YouZhi Ma,
Yilong Hou,
Fa-Zheng Wang,
QingPo Yang,
Yong Qi,
Changpeng Xu
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s346627
Subject(s) - osteomyelitis , cefazolin , medicine , staphylococcus aureus , orthopedic surgery , bone infection , pathology , surgery , antibiotics , biology , microbiology and biotechnology , genetics , bacteria
Osteomyelitis is characterized by intensive inflammatory bone disease and remains a clinical challenge in orthopedic surgery, despite the advances made in medical and surgical therapies. Staphylococcus aureus is a major causative agent of osteomyelitis, causing the progressive inflammatory destruction of bone. Prophylaxis of osteomyelitis during orthopedic surgery is necessary. NFκB essential modulator-binding domain (NBD) peptides are cell-permeable peptide inhibitors of the IκB-kinase complex. The prophylactic effect of NBD peptides in relieving inflammation and inhibiting bone defects in osteomyelitis is still under investigation. Our purpose was to determine the preventive effect of NBD peptides in S. aureus infection-induced bone defects in osteomyelitis.