Open AccessIdentification of Significant Modules and Targets of Xian-Lian-Jie-Du Decoction Based on the Analysis of Transcriptomics, Proteomics and Single-Cell Transcriptomics in Colorectal Tumor
Author(s) -
Caoyang Yu,
Tongqing Chen,
Sizhao Lu,
Wenlong Hu,
Qinchang Zhang,
Jiani Tan,
Dongdong Sun,
Liu Li,
Xin Sun,
Xu Chen,
Yueyang Lai,
Minmin Fan,
Zhengjie Shen,
Weixing Shen,
Haibo Cheng
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s344861
Subject(s) - colorectal cancer , medicine , transcriptome , proteomics , mechanism (biology) , cancer research , oncology , cancer , biology , gene expression , gene , biochemistry , philosophy , epistemology
Colorectal cancer (CRC) remains the third most common tumor worldwide. Ulcerative colitis (UC) could cause chronic inflammation and ulcers in the colon and rectum. UC is a risk factor for a high incidence of CRC, and the incidence of UC-associated CRC (UC-CRC) is still increasing. Chinese medicine prescription, Xian-Lian-Jie-Du decoction (XLJDD), has been proven its efficacy in some UC-CRC patients. However, the mechanism of XLJDD in treating UC-CRC remains unknown. This study aimed to investigate the mechanism of XLJDD in treating UC-CRC.