Open AccessUCHL1 Promoted Polarization of M1 Macrophages by Regulating the PI3K/AKT Signaling Pathway
Author(s) -
Yulan Huang,
Shitong He,
Yitian Chen,
Junli Sheng,
Yuling Fu,
Xialin Du,
Yalong Yang,
Honglin Liu,
Zhenyu Han,
Yingqi Huang,
Qian Wen,
Chaoying Zhou,
Xinying Zhou,
Shengfeng Hu,
Li Ma
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s343487
Subject(s) - ubiquitin , microbiology and biotechnology , macrophage polarization , cd86 , autophagy , downregulation and upregulation , pi3k/akt/mtor pathway , regulator , protein kinase b , biology , cd80 , signal transduction , macrophage , chemistry , in vitro , phenotype , apoptosis , biochemistry , gene , cd40 , cytotoxic t cell
As deubiquitinases (DUBs), ubiquitin C-terminal hydrolase (UCH)-L1 has been shown to play a crucial role in regulating diverse biological processes. However, its function in macrophage polarization remains unclear.