Open AccessToll-Like Receptor 4 Polymorphisms (896A/G and 1196C/T) as an Indicator of COVID-19 Severity in a Convenience Sample of Egyptian Patients
Author(s) -
Sara Taha,
Aalaa K. Shata,
Shereen A. Baioumy,
Shaimaa H Fouad,
Sherif G Anis,
Isis M. Mossad,
Nouran Moustafa,
Dina Abdou,
Mariam Youssef
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s343246
Subject(s) - covid-19 , sample (material) , toll like receptor , virology , medicine , genetics , receptor , biology , chemistry , chromatography , disease , innate immune system , infectious disease (medical specialty) , outbreak
The clinical spectrum of COVID-19 is extremely variable. Thus, it is likely that the heterogeneity in the genetic make-up of the host may contribute to disease severity. Toll-like receptor (TLR)-4 plays a vital role in the innate immune response to SARS-CoV-2 infection. The susceptibility of humans to severe COVID-19 concerning TLR-4 single nucleotide polymorphisms (SNPs) has not been well examined.