Open AccessChinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury
Author(s) -
Yiye Zhu,
Guoshun Huang,
Yang Yang,
Yong Chen,
Xiang Yu,
Gang Wang,
Yi Lan,
Kun Gao,
Fang Tian,
Shushu Qian,
Enchao Zhou,
Zou Yan-qin
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s341598
Subject(s) - inflammasome , pyroptosis , sod2 , inflammation , podocyte , proinflammatory cytokine , kidney , pharmacology , chemistry , medicine , superoxide dismutase , immunology , proteinuria , oxidative stress
Proteinuria is an independent risk factor of chronic kidney disease (CKD). Albumin-induced tubulointerstitial inflammation and epithelial-mesenchymal transition (EMT) via the activation of NLRP3 inflammasome is a potential therapeutic target for CKD. Suyin Detoxification Granule (SDG) improves proteinuria and postpones renal failure. However, the underlying mechanism is still unknown.