Open AccessThe Multi-Omics Analysis of Key Genes Regulating EGFR-TKI Resistance, Immune Infiltration, SCLC Transformation in EGFR-Mutant NSCLC
Author(s) -
Zhi Wang,
Lingling Zhang,
Wenwen Xu,
Jie Li,
Yi Liu,
Xiaozhu Zeng,
Ming Zhong,
Zhu Yu-xi
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s341001
Subject(s) - lung cancer , cancer research , epidermal growth factor receptor , adenocarcinoma , biology , gene , microrna , cancer , oncology , medicine , genetics
Lung cancer is a high-risk malignancy worldwide. The harboring of epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) makes EGFR-tyrosine kinase inhibitor (EGFR-TKI) an attractive therapeutic option. However, patients usually suffer the primary and secondary resistance to EGFR-TKI. And the molecular alteration is still not fully clear and needs further study.