Open AccessGarlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects
Author(s) -
Ayman Mousa,
Khaled E.A. Soliman,
Fahad A. Alhumaydhi,
Ahmad Almatroudi,
Osamah Al Rugaie,
Khaled S. Allemailem,
Faris Alrumaihi,
Arif Khan,
Mohamad Yosof Rezk,
Mohammad Abdullah Aljasir,
Ameen S. S. Alwashmi,
Faris F. Aba Alkhayl,
Aqel Albutti,
Hanan S. Seleem
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s339092
Subject(s) - pharmacology , antioxidant , gpx1 , chemistry , proliferating cell nuclear antigen , glutathione peroxidase , medicine , superoxide dismutase , biochemistry , immunohistochemistry
Trastuzumab is a new biological drug that has been used to treat breast and gastric cancer; however, its cardiotoxicity and hepatotoxicity limit its use. Garlic has antioxidant, anti-inflammatory, antihyperlipidemic, and anticancer effects. The present study aimed to evaluate the effects of garlic on trastuzumab-induced hepatotoxicity in a rat model.