Open AccessIL-17 is a Potential Therapeutic Target in a Rodent Model of Otitis Media with Effusion
Author(s) -
Nanfeng Zhang,
Tingting Qian,
Shan Sun,
Wei Cao,
Zhixian Wang,
Danling Liu,
Peifan Li,
Jing Wu,
Huawei Li,
Jing Yang
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s338598
Subject(s) - kegg , pathogenesis , immunofluorescence , western blot , otitis , inflammation , biology , immunology , pathology , microbiology and biotechnology , medicine , antibody , gene expression , gene , biochemistry , transcriptome , genetics
Otitis media with effusion (OME) is a non-suppurative inflammation of the middle ear that is characterized by middle ear effusion and hearing loss. However, the mechanisms of OME are not fully understood. The aim of this study was to determine the function and the mechanism of the IL-17 cytokine in the pathogenesis of OME and to investigate IL-17 as a potential strategy for the treatment of OME.