Open AccessGasdermin D in Different Subcellular Locations Predicts Diverse Progression, Immune Microenvironment and Prognosis in Colorectal Cancer
Author(s) -
Jiahui Wang,
Yixin Kang,
Yuxuan Li,
Liang Sun,
Jun Zhang,
Suhui Qian,
Ke Luo,
Yi Jiang,
Lichao Sun,
Fan Xu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s338584
Subject(s) - pyroptosis , cd68 , colorectal cancer , immunohistochemistry , cd8 , tumor infiltrating lymphocytes , cd3 , medicine , tumor microenvironment , tumor progression , immune system , pathology , cancer , cancer research , biology , immunology , inflammation , inflammasome
Pyroptosis is a type of cell death that causes an immune reaction. Gasdermin D (GSDMD), as an executor of pyroptosis, has become an attractive target in cancer research. However, the clinical significance of GSDMD expression in different subcellular locations remains unclear.