Open AccessConstruction of ceRNA Network to Reveal Potential Biomarkers in Crohn’s Disease and Validation in a TNBS Induced Mice Model
Author(s) -
Chenglin Ye,
Sizhe Zhu,
Jingping Yuan
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s338053
Subject(s) - competing endogenous rna , biology , immune system , computational biology , microrna , rna interference , gene , rna , immunology , long non coding rna , genetics
We aimed to construct a competing endogenous RNA (ceRNA) network and explore the potential biomarkers in Crohn's disease (CD) via bioinformatics analysis. Validation of candidate biomarkers in a 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced experimental colitis model and ceRNA network in an HCT116 cell line was also an aim, along with purposing to reveal the pathogenesis of CD.