Open AccessCross-Talk Between Nitrosative Stress, Inflammation and Hypoxia-Inducible Factor in Patients with Adrenal Masses
Author(s) -
Barbara Choromańska,
Piotr Myśliwiec,
Tomasz Kozłowski,
Magdalena Łuba,
Piotr Wojskowicz,
Jacek Dadan,
Hanna Myśliwiec,
Katarzyna Choromańska,
Katarzyna Makarewicz,
Anna Zalewska,
Mateusz Maciejczyk
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s337910
Subject(s) - peroxynitrite , nitrotyrosine , myeloperoxidase , nitric oxide , medicine , endocrinology , inflammation , aldosterone , hypoxia (environmental) , tumor necrosis factor alpha , chemistry , nitric oxide synthase , biochemistry , enzyme , oxygen , organic chemistry , superoxide
Adrenal masses are the most common of all human tumors. The role of nitrosative stress and inflammation in cancer development has already been demonstrated. However, it is not known whether they are involved in the pathogenesis of adrenal tumors. The aim of the study was to investigate a cross-talk between nitrosative stress, inflammation and hypoxia-inducible factor (HIF-1α) in 75 patients with different types of adrenal masses (non-functional incidentaloma, pheochromocytoma and Cushing's/Conn's adenoma).