Open AccessPeripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease: miRNA and mRNA Regulation
Author(s) -
Lijing Wang,
Hongjun Zhao,
Indu Raman,
Mei Yan,
Qiong Chen,
Quan-Zhen Li
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s337894
Subject(s) - microrna , transcriptome , biology , copd , microarray , microarray analysis techniques , peripheral blood mononuclear cell , downregulation and upregulation , gene expression , gene , regulation of gene expression , gene expression profiling , fold change , immunology , medicine , genetics , in vitro
The mechanisms underlying chronic obstructive pulmonary disease (COPD) remain unclear. Genetic and genomic changes may play a significant role in the pathogenesis of COPD. Identification of differentially expressed genes and miRNAs and their regulatory mechanisms at the whole-genome level will provide a comprehensive understanding of the development of COPD.