Open AccessMelatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats
Author(s) -
Shuqi Jiang,
Hong Wang,
Qiuping Zhang,
Qian Li,
Nan Liu,
Zhenggong Li,
Chunbo Chen,
Yiyu Deng
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s337499
Subject(s) - astrocyte , microglia , astrocytosis , western blot , immunofluorescence , biology , endocrinology , gliosis , medicine , white matter , neuroinflammation , myelin , pathology , inflammation , immunology , neuroscience , central nervous system , biochemistry , antibody , radiology , gene , magnetic resonance imaging
Astrocyte A1/A2 phenotypes may play differential role in the pathogenesis of periventricular white matter (PWM) damage in septic postnatal rats. This study aimed to determine whether melatonin (MEL) would improve the axonal hypomyelination through shifting A1 astrocytes towards A2.