Open AccessDistinct Polarization Dynamics of Microglia and Infiltrating Macrophages: A Novel Mechanism of Spinal Cord Ischemia/Reperfusion Injury
Author(s) -
Hui Li,
Pengfei Wang,
Lin Tang,
Jingjing Sun,
Yanling Zhang,
Wei Luo,
Cong Luo,
ZhaoLan Hu,
Lin Yang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s335382
Subject(s) - microglia , spinal cord , medicine , pathology , spinal cord injury , inflammation , ischemia , reperfusion injury , neuroprotection , immunology , pharmacology , psychiatry
Recent studies indicate that microglia and monocyte-derived macrophages (MDMs) have different roles in diseases such as stroke and spinal cord injury, yet their respective polarized phenotypes and roles remain unclear in spinal cord ischemia/reperfusion injury (SCIRI).