Open AccessTumor Necrosis Factor-α Gene Polymorphism is Associated with Short- and Long-Term Kidney Allograft Outcomes
Author(s) -
Felix Poppelaars,
Mariana Gaya da Costa,
Bernardo Faria,
Siawosh K. Eskandari,
Marc A. Seelen,
Jeffrey Damman
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s334738
Subject(s) - hazard ratio , kidney transplantation , medicine , kidney , immunosuppression , odds ratio , transplantation , genotype , gastroenterology , immunology , biology , confidence interval , gene , genetics
Kidney transplantation has excellent short-term results with current immunosuppression regimes, but long-term outcomes have barely improved over the past two decades. Hence, there is a need for new therapeutic options to increase long-term survival of kidney grafts. Drug development for kidney transplantation has slowly plateaued, limiting progress while making drug repurposing an attractive alternative. We, therefore, investigated the impact of tumor necrosis factor-alpha (TNF-α) gene ( TNF ) polymorphisms on kidney graft survival after transplantation.