Open AccessCASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor
Author(s) -
Zou C,
Jordan A. Beard,
Guoping Yang,
Evans We,
Bonten EJ
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s333725
Subject(s) - inflammasome , biosensor , chemistry , nalp3 , biochemistry , receptor
Following our 2015 elucidation of the CASP1/NALP3 inflammasome mechanism of glucocorticoid (GC)-resistance in pediatric acute lymphoblastic leukemia (ALL) patients, we engineered a cell-based CASP1/NALP3 reporter system suitable for high-throughput screening (HTS) of small molecule libraries, with the purpose of identifying compounds capable of inhibiting the CASP1/NALP3 inflammasome and synergizing with GC drugs for the treatment of GC-resistant ALL patients and various autoinflammatory diseases.