Open AccessThe β3/5 Integrin-MMP9 Axis Regulates Pulmonary Inflammatory Response and Endothelial Leakage in Acute Lung Injury
Author(s) -
Yao Tong,
Chengrong Bao,
Yi-Qiong Xu,
Lina Tao,
Yao Zhou,
Lei Zhuang,
Ying Meng,
Hui Zhang,
Jingjing Xue,
Weijun Wang,
Lele Zhang,
Qingbo Pan,
Zhongcai Shao,
Tianran Hu,
Qian Guo,
Qiao Xue,
Lu Han,
Yan Luo
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s331939
Subject(s) - evans blue , gene knockdown , lipopolysaccharide , mmp9 , vascular permeability , proinflammatory cytokine , immunology , endothelial stem cell , inflammation , matrix metalloproteinase , chemistry , medicine , pharmacology , apoptosis , downregulation and upregulation , in vitro , biochemistry , gene
Acute lung injury (ALI) is a severe respiratory disease with high rates of morbidity and mortality. Many mediators regarding endogenous or exogenous are involved in the pathophysiology of ALI. Here, we have uncovered the involvement of integrins and matrix metalloproteinases, as critical determinants of excessive inflammation and endothelial permeability, in the regulation of ALI.