Open Accessβ-Hydroxybutyrate Mitigated Heart Failure with Preserved Ejection Fraction by Increasing Treg Cells via Nox2/GSK-3β
Author(s) -
Shengen Liao,
Yuan Tang,
Xin Yue,
Rongrong Gao,
Wenming Yao,
Yanli Zhou,
Haifeng Zhang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s331320
Subject(s) - ejection fraction , heart failure , cardiac function curve , inflammation , medicine , nadph oxidase , myocardial fibrosis , fibrosis , cardiac fibrosis , downregulation and upregulation , endocrinology , ventricular remodeling , oxidative stress , chemistry , biochemistry , gene
This study was designed to investigate the cardioprotective role of β-hydroxybutyrate (BHB) in heart failure with preserved ejection fraction (HFpEF) and the underlying mechanism.