Open AccessIrreversible Electroporation Plus Anti-PD-1 Antibody versus Irreversible Electroporation Alone for Patients with Locally Advanced Pancreatic Cancer
Author(s) -
Chaobin He,
Shuxin Sun,
Yu Zhang,
Shengping Li
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s331023
Subject(s) - irreversible electroporation , medicine , adverse effect , pancreatic cancer , gastroenterology , electroporation , cancer , vomiting , immune system , surgery , immunology , biochemistry , chemistry , gene
Irreversible electroporation (IRE) is shown to not only improve the prognosis of patients with locally advanced pancreatic cancer (LAPC) but also activate the immune system. Considering the immune-activating function of IRE, IRE may enhance the effect of immune checkpoint inhibitors in the treatment of LAPC. We aimed to compare the effect and safety of IRE combined with toripalimab versus IRE alone for LAPC.