Open AccessB-Cell Deficiency Exacerbates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice
Author(s) -
Weixuan Zeng,
Guojing Liu,
Qingxian Luan,
Changzheng Yang,
Shiyi Li,
Xiaoqian Yu,
Li Su
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s330875
Subject(s) - periodontitis , rankl , osteoprotegerin , medicine , dental alveolus , inflammation , osteoclast , porphyromonas gingivalis , immunology , cytokine , pathology , receptor , activator (genetics) , dentistry
Periodontitis, one of the most prevalent chronic oral infectious diseases in humans, is induced by the breakdown in the balance between the biofilm and host immune system. Previous studies have shown the presence of large numbers of B cells in periodontitis lesions, implicating that B lymphocytes play a predominant role during the pathogenesis of periodontitis. This study aimed to investigate the role of all B cells in the initiation of periodontitis.