Open AccessCurcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota
Author(s) -
Yunyan Zhang,
Xuelian Li,
Xinghua Li
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s330499
Subject(s) - oxidative stress , inflammation , medicine , nonalcoholic fatty liver disease , hepatocellular carcinoma , tumor necrosis factor alpha , antioxidant , endocrinology , carcinogen , gut flora , interleukin , interleukin 6 , cytokine , fatty liver , chemistry , immunology , disease , biochemistry
Nonalcoholic fatty liver disease (NAFLD) increased the risk factor of hepatocellular carcinoma (HCC). NAFLD induces the hepatic-related cancer deaths mostly in middle-aged men. NAFLD enhanced the inflammatory reaction and oxidative stress in the hepatic tissue. Curcumae exhibited the anti-inflammatory and antioxidant effects. In this study, we made an attempt to scrutinize the protective effect of curcumae on obesity-induced HCC via alteration of inflammation, oxidative stress and gut microbiota.