Open AccessMaternal High-Fat Diet Programs Renal Peroxisomes and Activates NLRP3 Inflammasome-Mediated Pyroptosis in the Rat Fetus
Author(s) -
Pei Zhou,
Hongyan Guan,
Yanyan Guo,
Liangliang Zhu,
Xiaomei Liu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s329972
Subject(s) - inflammasome , oxidative stress , offspring , endocrinology , medicine , biology , fetus , sod2 , antioxidant , kidney , superoxide dismutase , inflammation , biochemistry , pregnancy , genetics
Maternal obesity impairs kidney development and function of the offspring and leads to a greater risk of kidney disease in adulthood. The present study aimed to investigate the link between peroxisomes, oxidative stress (OS), and inflammasomes in the fetal kidney of maternal obesity rats and to explore the potential therapeutic effects of the antioxidant pyrroloquinoline quinone (PQQ).