Open AccessDifferent Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages
Author(s) -
Chun-Yi Lai,
Po-Chun Tseng,
ChiaLing Chen,
Rahmat Dani Satria,
Yung-Ting Wang,
Chiou–Feng Lin
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s329921
Subject(s) - thp1 cell line , integrin alpha m , cd68 , flow cytometry , macrophage , cellular differentiation , microbiology and biotechnology , chemistry , phorbol , immune system , cell culture , biology , immunology , signal transduction , protein kinase c , immunohistochemistry , in vitro , biochemistry , gene , genetics
Phorbol 12-myristate 13-acetate (PMA)-induced differentiation of human monocytic THP-1 cells is an experimental model for preparing resting macrophages (M 0 ) for cell polarization toward the different functional specializations of macrophages.