Open AccessThe Effects of Adoptively Transferred IL-23/IL-18-Polarized Neutrophils on Tumor and Collagen-Induced Arthritis in Mice
Author(s) -
Yifang Chen,
Yang Li,
Han Guo,
Zhaoqi Zhang,
Jiayu Zhang,
Xue Dong,
Yi Liu,
Yuan Zhuang,
Yong Zhao
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s329528
Subject(s) - flow cytometry , interleukin 17 , immunology , adoptive cell transfer , inflammation , arthritis , bone marrow , interleukin 23 , biology , immune system , cancer research , microbiology and biotechnology , t cell
Neutrophils present great diverse phenotypes in various microenvironments and play different immune regulatory functions. Neutrophils generally classified into inflammatory phenotype N1 and anti-informatory phenotype N2. Our recent studies showed that IL-23 alone stimulated neutrophils to express IL-17A, IL-17F and IL-22 and displayed a gene transcriptional profile similar to Th17 cells. In the present study, we tried to identify potential cytokines to promote IL-23-induced neutrophil polarization.